A variety of experimental drugs have been used to treat experimental infections of B. felis in domestic cats. Trials have provided variable and questionable results. Studies have also suggested that repeated or chronic antiprotozoal therapy may be necessary to effectively treat feline Babesiosis.

Blood transfusion may be required in severe cases of anaemia.

Note for veterinarians: For a more exhaustive list of potential antiparasitic drugs, consult table 77-3 in Greene’s Infectious Diseases of the Dog and Cat.