Clinical Signs & Symptoms:

Lethargy (weakness / loss of energy)
Pyrexia (fever)
Mucous membrane pallor
Splenomegaly (enlarged spleen)
Lymphadenopathy (swollen / enlarged lymph nodes)
Haemolytic anaemia (anaemia caused by the destruction of red blood cells)
Haemoglobinuria (dark red haemoglobin-containing urine)
Icterus (Jaundice – yellowing of the skin and eyes that is caused by too much bilirubin in the blood)
Anorexia (loss of appetite leading to weight loss)
Tachycardia (rapid heart rate)
Tachypnea (rapid breathing)

In severe cases: acute collapse, multiple organ failure, and deathLaboratory investigations may document low red blood cell and platelet counts, abnormally low blood level of albumin, and bilirublin in the urine.

Initially, the anaemia can be normocytic, normochromic, and nonregenerative, but later develops into macrocytic, hypochromic, regenerative anaemia with reticulocytosis. The anaemia is hypochromic because the reticulocytes have not yet formed their adult concentrations of haemoglobin.