Dogs infected with B. canis usually respond to treatment with Imidocarb dipropionate at a dose of 6mg/kg I.M. administered twice at 14-day intervals. A higher dose administered once is recommended occasionally but can result in neurotoxicity. Another possible treatment is a single I.M. injection of Diminazene aceturate at a dosage of 5mg/kg.
Babesia gibsoni is considered more difficult to treat than B. canis. Recommended treatment protocols for B. gibsoni involve combining Atovaquone @ 13mg/kg PO q8h for 10 days, with Azithromycin @ 10mg/kg PO q24h for 10 days; Imidocarb dipropionate is not considered effective for treating B. gibsoni.
Babesia species infections can also be treated with Pentamidine isethionate @ 16mg/kg I.M q24h for 2 doses.
Treatment for Babesiosis reduces parasitaemia and supports resolution of clinical signs, although the infection itself may not be eliminated. Dogs diagnosed with Babesia species should be considered to be permanent carriers of the infection.
Note for veterinarians: For a more exhaustive list of potential antiparasitic drugs, consult table 77-3 in Greene’s Infectious Diseases of the Dog and Cat.