Doxycycline, Amoxicillin, Enrofloxacin, and Rifampin have all proved to be effective in reducing the level, and possibly the duration, of bacteraemia in the infected cat.

Doxycycline is used in the treatment of certain Bartonella species. However, data from experimentally and naturally infected cats indicates that a high dose (10mg/kg q12h for 4-6 week) may be necessary to eradicate infection of Bartonella henselae in both cats and dogs.

Follow-up cultures should be done at 2-4 week intervals to check treatment efficacy. Treatment is not always necessary but should definitely be pursued if the animal’s owner is immunocompromised.