Bartonella infections are generally treated with macrolides, tertracyclines, aminoglycosides, or chloramphenicol. The latter is not usually used to treat either B. henselae or B. quintana infections, although it has been used to treat B. bacilliformis.

Duration of therapy is commonly at least three weeks, but longer courses may be required for disseminated disease. Because these infections often fail to respond to therapy, or patients experience relapse later, switching to antibiotics from other classes may be needed.